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目的随机对比观察两种剂量辛伐他汀对急性冠脉综合征治疗后hs-CRP水平的影响。方法所有临床确定为ACS急性冠状动脉综合征患者,按随机原则分别入选辛伐他汀20mg及40mg组治疗4周,同时测定治疗前,治疗2周及4周时hs-CRP水平的变化。结果40mg组hs-CRP治疗前后差值与对照组、20mg组治疗前后差值有显著意义,治疗前后同组内比较亦有显著差异,40mg组作用优于20mg组。结论短期应用辛伐他汀治疗可明显减少炎症反应,稳定动脉粥样斑块,40mg组作用优于20mg。
Objective To investigate the effect of simvastatin on hs-CRP levels in patients with acute coronary syndrome (ACS) after randomized controlled trials. Methods All patients with acute coronary syndrome were enrolled in the study. The patients were randomly assigned to simvastatin 20 mg and 40 mg for 4 weeks respectively. Changes of hs-CRP levels were also measured before treatment, 2 weeks and 4 weeks after treatment. Results Before and after hs-CRP treatment, the difference between before and after treatment of hs-CRP in the control group and 20 mg group was significant. Before and after the treatment, there was also significant difference between the two groups. The 40 mg group was better than the 20 mg group. Conclusion Short-term use of simvastatin treatment can significantly reduce the inflammatory response, stable atherosclerotic plaque, 40mg group better than 20mg.