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视网膜母细胞瘤蛋白结合锌指结构基因(retinoblastoma protein-interacting zinc finger gene,RIZ)是由Buyse等[1]应用Rb探针在对可与Rb结合的蛋白质进行功能性筛选时分离出来的,RIZ基因由于转录起始位点的不同可表达RIZ1以及RIZ2两种蛋白质,RIZ1基因属于核组蛋白甲基转移酶超家族[2],是新近发现的肿瘤抑制基因。现就RIZ1基
The retinoblastoma protein-interacting zinc finger gene (RIZ) was isolated by Buyse et al [1] using a Rb probe for functional screening of proteins that bind to Rb. RIZ The gene can express two kinds of RIZ1 and RIZ2 proteins because of different transcription initiation sites. The RIZ1 gene belongs to the nuclear histone methyltransferase superfamily [2] and is a recently discovered tumor suppressor gene. Now RIZ1 base