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目的:研究血管紧张素转换酶2(ACE2)基因多态性与高血压患者血压昼夜节律变化的关系。方法:选择符合入选标准的高血压患者336例,采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)的方法,进行ACE2基因分型。根据血压昼夜节律变化,将高血压患者分为勺型与非勺型两组。分析基因型是否为非勺型血压的危险因素。结果:男性勺型组与非勺型组ACE2基因型多态性的分布存在显著差异,勺型组以G等位基因携带者为主。结论:ACE2基因多态性与男性高血压患者血压昼夜节律相关,携带G等位基因的患者可能更易发生夜间血压升高。
Objective: To investigate the relationship between the ACE2 gene polymorphism and the changes of circadian rhythm of blood pressure in hypertensive patients. Methods: A total of 336 hypertensive patients were enrolled in this study. ACE2 genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). According to the circadian rhythm of blood pressure, patients with hypertension were divided into two groups: scoop-shaped and non-scoop-shaped. Analysis of genotypes whether non-spoon-type blood pressure risk factors. Results: There were significant differences in the distribution of polymorphisms of ACE2 genotypes between male and non-scooping subjects, with G allele carriers predominant in the scooping group. CONCLUSIONS: ACE2 polymorphism is associated with circadian rhythm of blood pressure in men with hypertension, and patients with G allele may be more likely to have nocturnal blood pressure.