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患者女,30岁。于1997年12月因失语约2h入院,3h前因牙痛口服芬必得胶囊2粒60mg,未服其它药物。既往无神经系统病变。查体可知神志清,精神软,抬入病房,双侧瞳孔等大等圆约2mm,对光反庆调节反射灵敏,口唇无紫绀。呼吸平稳,不能发声,血压正常,四肢肌张力正常。用地塞米松注射液5mg肌注,症状无明显改变,给予地塞米松注射液10mg加入10％葡萄糖注射液500ml静滴,40min后症状逐渐消失,发声正常。 芬必得一般不良反应为胃、肠部不适或皮疹、头痛、耳鸣,偶在极少数患者中会出现支气管痉孪。此例中患者出现发声困难实属少见,故特此报道,提请广大临床医生引起重视。
Female patient, 30 years old. In December 1997 due to aphasia about 2h admission, 3h before the toothache oral Fenbid capsules 2 capsules 60mg, did not take other drugs. No previous nervous system disease. Physical examination shows clear mind, the spirit of soft, carried into the ward, bilateral pupil and other large round about 2mm, anti-reflective regulation of light sensitive, lips without cyanosis. Breathing stable, can not sound, normal blood pressure, limb muscle tone normal. Dexamethasone injection 5mg intramuscular injection, no significant change in symptoms, give dexamethasone injection 10mg 10% glucose injection 500ml intravenous infusion, 40min after the symptoms gradually disappear, the sound is normal. The usual side effects of fenbid are stomach, intestinal discomfort or skin rash, headache, tinnitus, even in very few patients with bronchospasm. In this case, it is rare for the patient to have sound problems. Therefore, it is hereby reported that drew the attention of clinicians.