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电离辐射诱发的基因组不稳定性在哺乳动物细胞和体内广泛的存在 ,使受照的细胞子代增加了遗传变化的频率。在辐射诱发小鼠白血病中 ,受预照射的 CBA/ H小鼠本身的白血病发生率与对照组相比并不显著 ,但子代小鼠中受γ射线照射后与单独受到γ射线照射的小鼠相比 ,白血病的潜伏期缩短 ,发病率增高。辐射诱发的基因组不稳定性可能使整基因组处于临界突变状态。随着基因组不稳定性过程使细胞内一些关键的基因 (如癌基因活化 ,抑癌基因失活 )突变 ,癌症发生。因此 ,基因组不稳定性在癌症的起始过程中作为一个关键的早期事件 ,可能起着特殊的 ,也许是独特的作用。
Ionizing radiation-induced genomic instability exists extensively in mammalian cells and in vivo, increasing the frequency of genetic changes in irradiated cell progeny. In radiation-induced murine leukemia, the incidence of leukemia in the pre-irradiated CBA/H mice was not significant compared with the control group, but the offspring were exposed to gamma rays alone and irradiated with gamma rays. Compared with rats, the latency of leukemia is shortened and the incidence rate is increased. Radiation-induced genomic instability may cause the entire genome to be in a critical mutation state. As the process of genomic instability causes mutations in some of the key genes in the cell (such as oncogene activation and tumor suppressor gene inactivation), cancer occurs. Therefore, genomic instability as a key early event in the initiation of cancer may play a special, perhaps unique, role.