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目的:研究影响2型糖尿病(T2DM)患者肝脏脂肪含量(LFC)的危险因素,并分析LFC与尿酸(UA)的相关性。方法:随机选择538例住院T2DM患者,采用超声定量LFC,并根据LFC水平分为3组:低水平组(LFC≤6.84%)、中等水平组(6.84%19.20%)。测量患者身高、体质量、腰围(WC),并计算体质量指数(BMI),测量收缩压(SBP)及舒张压(DBP),并测定UA、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)等指标;分析LFC与UA的相关性,并利用多元线性逐步回归分析法分析影响LFC的危险因素。结果:随着LFC的增加,各组WC、BMI、DBP、TG、UA值逐步增加,而年龄、糖尿病病程逐步减小(P<0.05);Logistic回归分析显示,年龄、糖尿病病程、BMI、TG、UA为影响LFC的独立危险因素;LFC与WC、BMI、DBP、TG、UA呈正相关性,校正WC、BMI、DBP、TG等指标后,LFC仍与UA显著相关。结论:T2DM患者LFC与UA呈显著正相关性,年龄、糖尿病病程、BMI、TG、UA为影响LFC的危险因素。
Objective: To study the risk factors of hepatic fat (LFC) in patients with type 2 diabetes mellitus (T2DM) and to analyze the association between LFC and uric acid (UA). Methods: A total of 538 hospitalized patients with T2DM were enrolled in this study. LFC was quantified by ultrasound and divided into three groups according to LFC level: low level group (LFC≤6.84%), middle level group (6.84% 19.20%). Body height, body weight, waist circumference (WC), body mass index (BMI), SBP and DBP were measured and UA, total cholesterol (TC) (HDL) and low density lipoprotein (LDL) were measured. The correlation between LFC and UA was analyzed. The risk factors affecting LFC were analyzed by multivariate linear stepwise regression analysis. Results: With the increase of LFC, the WC, BMI, DBP, TG and UA increased gradually in all groups, while the course of diabetes and diabetes decreased gradually (P <0.05). Logistic regression analysis showed that age, duration of diabetes, BMI, TG UA was an independent risk factor affecting LFC. LFC was positively correlated with WC, BMI, DBP, TG and UA. After adjusting for WC, BMI, DBP, TG and other indicators, LFC was still significantly associated with UA. CONCLUSION: There is a significant positive correlation between LFC and UA in T2DM patients. Age, duration of diabetes, BMI, TG and UA are the risk factors of LFC.