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8-氨基喹啉是存在于天然产物和药物分子中的一种重要含氮芳香杂环化合物;可作为有机配体或者双齿导向基团参与一系列有机合成反应,在材料领域也有着广泛应用,因而,受到越来越多的研究者青睐.近年来通过对喹啉母环结构进行位置选择性修饰,构建单取代及多取代喹啉取得了飞速发展.本综述较全面地总结近年来通过碳氢活化方法构建C(5)位取代8-氨基喹啉衍生物的进展,对该领域所存在的问题和局限性进行了总结,并对今后的发展作出展望.
8-Aminoquinoline is an important nitrogen-containing aromatic heterocyclic compound existing in natural products and drug molecules. It can participate in a series of organic synthesis reactions as an organic ligand or a bidentate guiding group and is also widely used in the field of materials , And therefore, more and more researchers favor.In recent years by the quinoline ring structure of the site-selective modification, the construction of mono-substituted and multi-substituted quinoline has made rapid development.This review is more comprehensive summary of recent years by Hydrocarbon activation method for the construction of C (5) substituted 8 - aminoquinoline derivatives progress, the problems and limitations in this area are summarized, and the future development prospects.