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Background: Diabetic nephropathy is one of severe complications of diabetes mellitus (DM). With the increasing of incidence of DM, diabetic nephropathy (DN) has become the most common cause of renal failure in the end stage. More and more patient receive treatment of dialysis and kidney transplantation. The effect of protein intake on pathophysiology of DN has been taken more and more seriously. Studies have shown that restriction of protein intake could delay the progress of renal failure, relieve symptoms of uremia, and provide good prognosis of DN. rn