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目的:探讨重症手足口病并发病毒性脑膜脑炎的临床特点和病程变化。方法:对2008年5月1日～8月1日在手足口病重症监护病房(ICU)确诊为重症手足口病并发病毒性脑膜脑炎住院患儿的临床特点及病程变化进行回顾性分析。结果:平均年龄(25.9±13.6)个月(2个月～5岁),热程(5.5±1.8)天(2～12天),手足口臀均有皮疹者50.0%,重症表现93.6%在病程4天内出现,100%在病程7天内出现,入院时随机血糖≥7.8mmol/L者平均住院日为(7.7±2.5)天,而血糖正常患儿平均住院日(5.9±2.4)天,其差异具有统计学意义(P=0.007),经治疗,85.1%的患儿在入院后4天内重症表现消失,100%在入院后6天内重症表现消失。结论:重症手足口病并发病毒性脑膜脑炎重症表现均在病程7天内出现,年龄1～3岁为多,皮疹以手足口臀均有者为多,其中血糖≥7.8mmol/L者住院时间明显延长,有效治疗后生命体征全部在入院后6天内稳定,平均住院(6.19±2.49)天(2～17天)。
Objective: To explore the clinical features and course of the disease of severe mehndod mouth complicated with viral meningoencephalitis. Methods: The clinical features and course of disease in hospitalized infants with severe hand-foot-mouth disease complicated with viral meningoencephalitis diagnosed in hand-foot-mouth disease intensive care unit (ICU) from May 1 to August 1, 2008 were analyzed retrospectively. Results: The mean age was (25.9 ± 13.6) months (ranged from 2 months to 5 years) and the thermal duration was 5.5 ± 1.8 days (ranged from 2 to 12 days). Rash was 50.0% The course of disease occurred within 4 days and 100% within 7 days. The mean hospital stay (7.7 ± 2.5) days for random glucose ≥7.8 mmol / L on admission and the average hospital stay (5.9 ± 2.4) days for normal blood glucose were The difference was statistically significant (P = 0.007). After treatment, 85.1% of children disappeared in 4 days after admission and 100% disappeared within 6 days after admission. Conclusions: Severe hand-foot-mouth disease complicated with severe viral meningoencephalitis occurred in 7 days. The age ranged from 1 to 3 years old. The skin rash was more in the hands, feet and mouth, in which the blood glucose≥7.8mmol / L was hospitalized Significantly prolonged, effective treatment of vital signs all within 6 days after admission stable, the average hospitalization (6.19 ± 2.49) days (2 to 17 days).