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Toll样受体是介导天然免疫的重要受体,它能够识别病原相关分子模式配体,直接启动有效的抗感染机制,为建立适应性免疫提供条件。最近研究发现Toll样受体尚能识别包括热休克蛋白在内的内源性配体,参与微生物诱导之外的免疫机制。
Toll-like receptors are important receptors for innate immunity. They recognize pathogen-associated molecular pattern ligands and directly initiate effective anti-infective mechanisms, providing conditions for establishing adaptive immunity. Recent studies have found that Toll-like receptors are still able to recognize endogenous ligands including heat shock proteins involved in immune mechanisms other than microbial induction.