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随着生物技术的不断发展,近来多肽药物的临床应用迅速增加。因多肽药物易在胃肠道降解,临床多采用注射给药。但注射常给患者带来痛苦,增加花费。经直肠、口腔、鼻腔、气管及皮下等途经给药也有尝试,但因种种原因均不易被患者接受。据报道0.5％的聚氧乙烯9—月桂醚(BL—9)和0.5％的聚氧乙烯20—硬脂醚(Brij—78)能显著增加青霉素的吸收而不引起眼刺激症状。本文观察BL—9和HBrij—78对生长激素释放抑制因子、血管
With the continuous development of biotechnology, the clinical application of polypeptide drugs has rapidly increased recently. Peptide drug easy to gastrointestinal degradation, the clinical use of injection. However, injection often gives patients pain and increase costs. Rectal, oral, nasal, tracheal and subcutaneous administration has also tried, but for various reasons are not easily accepted by patients. It has been reported that 0.5% of polyoxyethylene 9-lauryl ether (BL-9) and 0.5% of Brij-78 can significantly increase penicillin absorption without causing ocular irritation. This article investigates the effects of BL-9 and HBrij-78 on the growth hormone releasing-inhibitory factor, vascular