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目的:探讨缓释渗透增敏化疗加放疗综合治疗食管癌的疗效.方法:采取食管缓释渗疗器局部缓释渗疗同时配合X线常规放疗50例食管癌,另50例行单纯常规分割X线外照射作为同期对照研究;观察近期疗效及1,3,5a生存率.结果:缓释渗透治疗组与单纯放疗组的完全缓解(CR),部分缓解(PR),CR+PR,无变化(NC),肿瘤进展(PD)分别为:55.1%,10%;40.8%,60%;95.9%,70%;0,20%;4.8%,10%.缓释渗透治疗组的CR,CR+PR,PR与单纯放疗组相比有显著性差异(P<0.01或P<0.05).生存情况:缓释渗透治疗组与单纯放疗组1a生存率为73.46%,52%(P<0.05);3a生存率为40.8%,28%(P>0.05);5a生存率为16.3%,0(P<0.005).结论:食管缓释渗疗器局部缓释渗疗配合常规分割放疗综合治疗食管癌,有显著的近期疗效;同时改善了患者的生存率.
Objective: To investigate the efficacy of sustained-release osmotic sensitization combined with radiotherapy in the treatment of esophageal cancer.Methods: 50 cases of esophageal cancer were treated with esophageal sustained- X-ray external irradiation was used as a control study in the same period.Clinical effects and 1,3,5-year survival rates were observed.Results: The rates of complete remission (CR), partial remission (PR), CR + PR, (NC) and tumor progression (PD) were 55.1%, 10%, 40.8%, 60%, 95.9%, 70%, 0,20%, 4.8%, 10% CR + PR, PR were significantly different from radiotherapy group (P <0.01 or P <0.05). Survival: The survival rates of delayed-release osmotic group and radiotherapy alone group 1a were 73.46% and 52% ); 3a survival rate was 40.8%, 28% (P> 0.05); 5a survival rate was 16.3%, 0 (P <0.005) .Conclusion: Local delayed-release oozing device combined with conventional radiotherapy Esophageal cancer, a significant short-term effect; while improving patient survival.