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随着心脏停搏液在心脏外科中的广泛应用,短期的心肌缺血已不再构成心脏手术的严重威胁。60年代初人们观察到对缺血后的心肌恢复正常的血供,可导入新的致伤成份,谓之再灌注性损伤。80年代以来大量的研究证明再灌注性损伤可出现在心内直视术后,冠状动脉主动脉傍路移植术、冠状动脉腔内成形术以及溶栓术后。本文综述有关心肌缺血再灌注损伤的发生机制、临床表现和特点、影响因素及其防治措施的研究进展。
With the widespread use of cardioplegia in cardiac surgery, short-term myocardial ischemia no longer poses a serious threat to heart surgery. In the early 1960s, it was observed that the blood supply to the post-ischemic myocardium returned to normal, leading to the introduction of a new traumatic component, which is referred to as reperfusion injury. Since the 1980s, a large number of studies have shown that reperfusion injury can occur after open heart surgery, coronary aortic bypass, coronary angioplasty and thrombolysis. This article reviews the research progress of myocardial ischemia-reperfusion injury mechanism, clinical manifestations and characteristics, influencing factors and preventive measures.