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为研究缺血小肠的再灌注损伤,阻断家兔SMA血流1小时或35mmHg低压灌流SMA2小时,然后以90mm Hg恒压再灌注2小时。结果发现缺血小肠再灌注后出现逐渐加重的组织损伤,表现为血浆ACP活性、乳酸和镁进行性增加,小肠粘膜出血,小肠绒毛坏死和组织水肿进行性加重,以及体动脉压降低,心肌缺血损伤等。这种再灌注损伤,甚至比小肠持续缺血3小时者更严重。本文对缺血小肠再灌注损伤在休克发病学中的意义进行了讨论。
To investigate reperfusion injury in ischemic small intestine, rabbit SMA blood flow was blocked for 1 hour or 35 mm Hg for 2 hours under low pressure and then for 2 hours at 90 mm Hg. The results showed that the gradual aggravating tissue injury occurred after reperfusion of ischemia reperfusion, showing the activity of plasma ACP, the progressive increase of lactate and magnesium, intestinal mucosal hemorrhage, intestinal villus necrosis and edema of the intestine aggravating, and arterial pressure decreased, myocardial ischemia Blood damage and so on. This reperfusion injury is even more severe than the duration of 3 hours of sustained ischemia in the small intestine. This article discusses the significance of ischemia-reperfusion injury in shock pathogenesis.