论文部分内容阅读
有关抗腹泻药理实验及其方法,国内文献未见报导,我们参考了F.Awoutors等介绍的方法,该法系以蓖麻油为致泻物,造成大白鼠腹泻模型,进行药物抗腹泻实验,测出ED50。我们选用了四种已知治疗腹泻药物进行实验,以计算出X~2值,测定显著性差异来判定药物是否有抗腹泻疗效,实验结果,四种药物均能看出抗腹泻作用。在此基础上同样用蓖麻油造成小白鼠腹泻模型,进行抗腹泻药理实验,结果与大白鼠一致,现将实验方法介绍如下:
As for the pharmacological experiments and methods of antidiarrhea, there are no reports in the domestic literature. We refer to the methods described by F. Awoutors et al., which uses castor oil as a cause of diarrhoea, causes rat model of diarrhea, and conducts antidiarrheal experiments for drugs. ED50. We used four known drugs for the treatment of diarrhea in order to calculate the X~2 value, and measured the significant difference to determine whether the drug has anti-diarrhea efficacy. The experimental results showed that all four drugs can see the anti-diarrhea effect. On this basis, castor oil was also used to cause the diarrhea model of white mice to perform pharmacological experiments against diarrhea. The results were consistent with that of rats. The experimental methods are now described as follows: