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目的观察中药复方苦参注射液联合介入化疗治疗晚期非小细胞肺癌的疗效。方法将59例晚期非小细胞肺癌患者随机分为两组:实验组30例,给予复方苦参+介入化疗;对照组29例,给予单纯介入化疗。比较两组的近期疗效、生存率及毒副反应。结果实验组与对照组近期有效率及12、24个月生存率均无显著差异;但两组临床获益率及6个月生存率均有显著差异,分别为93.3%(实验组)vs72.4%(对照组)和96.6%vs72.4%(P<0.05);且实验组毒副反应较对照组明显减轻。结论在介入化疗治疗非小细胞肺癌的同时给予复方苦参注射液能够起到稳定瘤灶、减轻毒副反应、提高生活质量的作用。
Objective To observe the curative effect of compound Kushenin injection combined with interventional chemotherapy in the treatment of advanced non-small cell lung cancer. Methods 59 patients with advanced non-small cell lung cancer were randomly divided into two groups: experimental group 30 cases, given Sophora japonica + interventional chemotherapy; control group, 29 cases were given simple interventional chemotherapy. The curative effect, survival rate and toxicity of the two groups were compared. Results There was no significant difference between the two groups in the recent efficiency and the 12 and 24-month survival rates. However, the clinical benefit rates and the 6-month survival rates were significantly different between the experimental group and the control group, 93.3% (experimental group) vs 72, respectively. 4% (control group) and 96.6% vs72.4% (P <0.05). The toxicity of the experimental group was significantly lower than that of the control group. Conclusion In the interventional chemotherapy for non-small cell lung cancer, compound Kushen injection can stabilize the tumor, reduce the side effects and improve the quality of life.