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目的研究原发性青光眼发生与发展过程中外用血淋巴细胞CD44及CD54表达量及其临床意义。方法28例原发性青光眼及28例健康人外周静脉血，经淋巴细胞分离、CD44-FITC及CD54-FITC免疫反应、流式细胞分析仪测定CD44及CD54表达量，并行统计学分析。结果原发性闭角型及开角型青光眼患者外周血淋巴细胞CD44及CD54表达量明显升高，与正常人比较，P＜0．01，差异有非常显著性意义。结论粘附分子CD44及CD54表达量升高与原发性青光眼发生与发展过程相关。CD44及CD54可能参与原发性青光眼发生与发展过程。
Objective To study the expression of CD44 and CD54 in peripheral blood lymphocytes during the development and progression of primary glaucoma and its clinical significance. Methods Peripheral blood was collected from 28 patients with primary glaucoma and 28 healthy controls. CD44-FITC and CD54-FITC immunoreactions were detected by lymphocyte separation. The expression of CD44 and CD54 were measured by flow cytometry and analyzed statistically. Results The expression of CD44 and CD54 in peripheral blood lymphocytes in primary angle-closure and open-angle glaucoma patients were significantly higher than those in normal controls (P <0.01). The difference was significant. Conclusion The increased expression of adhesion molecules CD44 and CD54 is related to the occurrence and development of primary glaucoma. CD44 and CD54 may be involved in the pathogenesis and progression of primary glaucoma.