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目的:观察胰激肽原酶与甲钴胺联合应用治疗糖尿病周围神经病变的疗效。方法:60例糖尿病周围神经病变患者随机分为治疗组及对照组,在常规治疗的基础上,治疗组用胰激肽原酶联合甲钴胺治疗,对照组用甲钴胺治疗,12周后进行疗效评定。结果:治疗组与治疗前比较,临床症状和体征明显改善,正中神经、尺神经及胫神经的运动神经传导速度(MCV)、感觉神经传导速度(SCV)显著增加(P<0.05);治疗组与对照组作治疗后比较,差异具有显著性(P<0.01)。结论:胰激肽原酶联合甲钴胺治疗糖尿病周围神经病变优于单用甲钴胺,疗效显著。
Objective: To observe the therapeutic effect of pancreatic kallikrein combined with mecobalamin in the treatment of diabetic peripheral neuropathy. Methods: Sixty patients with diabetic peripheral neuropathy were randomly divided into treatment group and control group. On the basis of routine treatment, the patients in the treatment group were treated with pancreatic kallikrein combined with mecobalamin and the control group were treated with methylcobalamin. After 12 weeks Efficacy assessment. Results: Compared with those before treatment, the clinical symptoms and signs of the treatment group were significantly improved. The motor nerve conduction velocity (MCV) and sensory nerve conduction velocity (SCV) of the median nerve, ulnar nerve and tibial nerve increased significantly (P <0.05) Compared with the control group after treatment, the difference was significant (P <0.01). Conclusion: Combination of pancreatic kallikrein and mecobalamin for the treatment of diabetic peripheral neuropathy is better than mecobalamin alone.