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目的：研究克拉霉素颗粒剂在健康人体内的药代动力学。方法：10名健康志愿者，单剂量口服克拉霉素片500mg，经时采集静脉血HPLC法测定血药浓度，药-时数据用3p87程序处理。结果：克拉霉素颗粒剂的药动学参数分别为：Tmax（1．89±0．60）h，Cmax（2.30±0.43）μg/ml，T1/2K（2．85±0.57）h，lagtime（0.06±0.03）h，V／F（139.8±40.3）L，AUC（16.61±2．80）μg／（h·ml）。结论：口服同剂量克拉霉素的药动学参数值与国外文献有明显的差异。
Objective: To study the pharmacokinetics of clarithromycin granules in healthy volunteers. Methods: Ten healthy volunteers were given a single oral dose of 500 mg clarithromycin. Blood samples were collected by HPLC for determination of drug concentration. The drug-hour data were processed by 3p87 program. Results: The pharmacokinetic parameters of clarithromycin granules were as follows: Tmax (1.89 ± 0.60) h, Cmax (2.30 ± 0.43) μg / ml, T1 / 2K (0.06 ± 0.03) h, V / F (139.8 ± 40.3) L, AUC (16.61 ± 2.80) μg / (h · ml). Conclusion: The oral dose of clarithromycin pharmacokinetic parameters with foreign literature there are significant differences.