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目的:评估血清甲状旁腺激素(PTH)、25-羟维生素D3[25(OH)D3]水平与2型糖尿病肾病的相关性。方法:选取自2010年1月至2015年1月我院收治的符合WHO诊断标准的198例T2DM患者,测定血清PTH、25(OH)D3以及Hb A1c等指标。结果:(1)2型糖尿病25(OH)D3缺乏的患病率为63.64%。(2)维生素D不足组和维生素D正常足组间相比,两组间OGTT餐后2小时血糖、24小时尿总蛋白、尿微量白蛋白差异有统计学差异(P<0.05)。(3)多元线性回归分析提示年龄、25(OH)D3、糖化血红蛋白与24小时微量白蛋白独立相关。结论:2型糖尿病患者25(OH)D3缺乏较常见,25(OH)D3水平是糖尿病肾病的独立相关因子,而PTH可能主要通过调节25(OH)D3影响尿蛋白含量。
PURPOSE: To evaluate the relationship between serum parathyroid hormone (PTH), 25-hydroxyvitamin D3 [25 (OH) D3] and type 2 diabetic nephropathy. Methods: A total of 198 patients with T2DM who met WHO diagnostic criteria from January 2010 to January 2015 were enrolled in this study. Serum PTH, 25 (OH) D3 and Hb A1c were measured. Results: (1) The prevalence of 25 (OH) D3 deficiency in type 2 diabetes was 63.64%. (2) There were significant differences in OGTT blood glucose, 24-hour urine total protein and urine microalbumin between the two groups at 2 hours after meal (P <0.05) compared with the normal vitamin D group. (3) Multivariate linear regression analysis showed that age, 25 (OH) D3, glycosylated hemoglobin and 24-hour microalbumin were independently related. CONCLUSION: 25 (OH) D3 deficiency is common in patients with type 2 diabetes mellitus, and 25 (OH) D3 is an independent factor related to diabetic nephropathy. PTH may affect urinary protein content mainly through the regulation of 25 (OH) D3.