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目的观察磷霉素钙甲氧苄啶与头孢克肟治疗小儿急性细菌性肠炎的疗效。方法将2008年4月至2010年10月本院门诊的急性细菌性肠炎患儿随机分为磷霉素组68例及头孢克肟组57例,观察两组治疗总有效率。结果磷霉素组总有效率为94.1%,头孢克肟组总有效率为91.2%,差异无显著性(P>0.05)。结论磷霉素钙甲氧苄啶与头孢克肟治疗小儿急性细菌性肠炎疗效相当,可根据患儿有无过敏及服药依从性选择,且两者无交叉耐药,如一种无效可换用另一种。
Objective To observe the efficacy of fosfomycin calcium and trimethoprim in the treatment of children with acute bacterial enteritis. Methods A total of 68 patients with acute bacterial enteritis in our hospital from April 2008 to October 2010 were randomly divided into fosfomycin group (68 cases) and cefixime group (57 cases). The total effective rate was observed in both groups. Results The total effective rate was 94.1% in the fosfomycin group and 91.2% in the cefixime group, with no significant difference (P> 0.05). Conclusion Fosfomycin calcium trimethoprim and cefixime in the treatment of children with acute bacterial enteritis is quite effective, according to whether the children have allergies and medication compliance, and no cross-resistance between the two, such as an invalid exchange for another A.