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目的探讨齐齐哈尔地区不良妊娠夫妇的染色体异常发生率。方法采用外周血淋巴细胞培养及染色体制备技术,进行染色体G显带核型分析。结果遗传咨询中,753对不良妊娠夫妇共检出异常核型119例,异常率为7.9%。结论染色体异常是导致不良妊娠的主要因素之一。对不良妊娠史夫妇进行遗传咨询及染色体核型分析,能够防止先天缺陷患儿的出生,对于提高全民的遗传素质有重要意义。
Objective To investigate the incidence of chromosomal abnormalities in couples with adverse pregnancy in Qiqihar area. Methods Chromosome G banding karyotype analysis was performed by using peripheral blood lymphocyte culture and chromosome preparation techniques. Results In the genetic counseling, a total of 753 abnormal karyotypes were detected in 753 couples with adverse pregnancy, with an abnormality rate of 7.9%. Conclusion Chromosomal abnormalities are one of the main causes of adverse pregnancy. Genetic counseling and karyotype analysis of couples with unhealthy pregnancies can prevent the birth of children with birth defects and are of great importance for improving the genetic quality of the entire population.