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目的 观察血药浓度监测对成人癫痫患者认知功能的影响。方法 对服用抗癫痫药治疗成人癫痫患者进行了血药浓度和认知功能的评定,观察其药物影响的特点。结果 (1)患者组在有效治疗浓度范围内认知功能提高,和调整用药前比较差别有显著性意义(P<0.05);(2)血药浓度与认知功能呈显著正相关(r=0.638,P<0.05)。结论 成人癫痫患者存在认知功能下降,血药浓度监测可指导合理用药,提高患者认知功能。
Objective To observe the effect of plasma concentration monitoring on cognitive function in adults with epilepsy. Methods The anti-epileptic drugs in patients with adult epilepsy were assessed blood concentration and cognitive function to observe the characteristics of its drug effects. Results (1) The cognitive function of the patients in the effective therapeutic concentration range was significantly improved (P <0.05). (2) There was a significant positive correlation between plasma concentration and cognitive function (r = 0.638, P <0.05). Conclusion There is a decline in cognitive function in adult patients with epilepsy. Monitoring blood concentration can guide rational use of drugs and improve cognitive function in patients.