论文部分内容阅读
目的探讨3.0T高场强MRI血氧水平依赖(blood oxygenation level depended,BOLD)和弥散张量成像(diffusion tensor imaging,DTI)在累及重要功能区脑肿瘤手术中应用价值。方法累及重要功能区肿瘤患者30例,均于术前应用BOLD技术确定皮层区与肿瘤的空间关系,在检查中针对患者肿瘤存在位置制订双手相向运动任务或朗读任务。术中电刺激确定功能区皮层,应用神经导航系统结合DTI显示的纤维走行确定手术入路。对皮质激活图像数据进行评估,并分为功能组15例,常规组15例,比较2组手术后KPS评分。结果 30例患者双手相向运动任务或朗读任务BOLD检查皮层区均有激活,激活区域与皮质电刺激相对应;术后功能组KPS评分(83.67±5.21)分较常规组(81.73±6.79)分高(P<0.05)。结论术前BOLD-MRI检查可准确显示功能皮层区与肿瘤间关系,联合神经导航及DTI信息用于肿瘤切除术中,可取得良好临床效果。
Objective To explore the value of 3.0T high field MRI in blood oxygenation level depended (BOLD) and diffusion tensor imaging (DTI) in the treatment of brain tumors involving in important functional areas. Methods Thirty patients with major functional tumor were included in the study. BOLD technique was used to determine the spatial relationship between the cortical area and the tumor before surgery. During the examination, two-hand motion-oriented tasks or reading tasks were established according to the location of the tumor. Intraoperative electrical stimulation to determine the function of the cortex, the application of nerve navigation system combined with DTI display of fiber walking to determine the surgical approach. Cortical activation image data were evaluated and divided into functional group of 15 cases, 15 cases of conventional group, the two groups were compared KPS score. Results 30 cases of patients with bilateral hand movement task or reading task BOLD examination cortical area were activated, activation area and cortical electrical stimulation corresponding functional group KPS score (83.67 ± 5.21) points than the conventional group (81.73 ± 6.79) points high (P <0.05). Conclusion Preoperative BOLD-MRI can accurately show the relationship between functional cortex and tumor. Combined with neuro-navigation and DTI information for tumor resection, good clinical results can be obtained.