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目的:观察米索前列醇配伍缩宫素预防产后出血的临床疗效。方法:选择足月妊娠、单胎头位、无妊娠并发症、无前列腺素禁忌证且近期内未用过前列腺素抑制剂的产妇119例,随机分为观察组(65例)和对照组(54例)。观察组在胎儿娩出后子宫肌注射缩宫素20 U,同时于产妇直肠内放置米索前列醇400μg;对照组在胎儿娩出后子宫肌注射缩宫素20 U。观察产后24 h内出血量及产后出血发生率。结果:观察组产后2 h、24 h内出血量及产后出血发生率明显低于对照组(P<0.01,P<0.01,P<0.05);观察组的第三产程时间明显少于对照组(P<0.01)。结论:米索前列醇配伍缩宫素能有效降低产后出血量、产后出血发生率及第三产程时间,值得临床推广使用。
Objective: To observe the clinical efficacy of misoprostol combined with oxytocin to prevent postpartum hemorrhage. Methods: One hundred and ninety-nine cases of full-term pregnancy, single head position, pregnancy-free complication, prostaglandin-free contraindication and no prostaglandin inhibitor in the near future were randomly divided into observation group (65 cases) and control group 54 cases). In the observation group, 20 U of oxytocin was injected into the uterine muscle after the fetus was delivered, and 400 μg of misoprostol was placed in the rectum of the fetus. In the control group, 20 U of oxytocin was injected into the uterine muscle after the fetus was delivered. Observe the amount of bleeding within 24 h postpartum and the incidence of postpartum hemorrhage. Results: The amount of hemorrhage and the incidence of postpartum hemorrhage in observation group within 24 hours and 24 hours postpartum were significantly lower than those in control group (P <0.01, P <0.01, P <0.05) <0.01). Conclusion: Misoprostol combined with oxytocin can effectively reduce the amount of postpartum hemorrhage, the incidence of postpartum hemorrhage and the third stage of labor, worthy of clinical promotion and use.