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作者对不同激素影响在脂代谢中的利弊进行了研究。单纯口服雌激素有利于脂蛋白代谢,但外源性雌激素可刺激宫内膜增生过长或导致宫内膜癌。加用孕激素可保护宫内膜,减少上述发生率,故雌孕激素联合治疗更有利。在月经周期的最后10人加用孕激素,可以减少撤退性出血和保持骨质的致密,比单一的雌激素治疗优越。研究对象为1983年哥本哈根城45～54岁270名妇女,均进行临床病史询问、妇科检查、细胞学试验、乳房扪诊,测血压和血标本检验。任选21名应用联合疗法:口服雌二醇2mg和醋酸炔诺酮1mg(?)28天为一周期;23名为安慰剂对照组。每3个月检查一次共5次。
The authors studied the pros and cons of the effects of different hormones in lipid metabolism. Oral estrogen alone is good for lipoprotein metabolism, but exogenous estrogen can stimulate endometrial hyperplasia or lead to endometrial cancer. Plus progesterone can protect the endometrium, reduce the incidence, so the combined treatment of estrogen and progesterone more favorable. In the last 10 menstrual cycles plus progesterone, can reduce the withdrawal of bleeding and maintain the dense bone, superior to single estrogen therapy. The study population was 270 women aged 45 to 54 in Copenhagen in 1983. They were asked about clinical history, gynecological examination, cytology test, breast palpation, blood pressure test and blood test. Twenty-one candidates for combination therapy were selected: oral estradiol 2 mg and norethindrone acetate 1 mg (?) For a period of 28 days; 23 were placebo-controlled. Check every 3 months for 5 times.