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患者住院号22507,女性,23岁,1980年6月21日因血行播散型肺结核合并结核性脑膜炎入院。用链霉素、异菸肼及静滴对氨柳酸钠,口服强地松治疗。于7月14日出现对氨柳酸钠所致的发烧、药疹等变态反应,停滴对氨柳酸钠后于7月23日并用利福平600毫克/日口服(锦州制药厂1980年产),至8月4日又开始发热、感双指尖麻木,并有恶心、呕吐等症状。8月11日发现双侧手掌及足蹠面呈橙红色,局部触觉及痛觉似稍减弱,其它处皮肤色泽正常,巩膜无黄染,肝功正常,黄疸指数5单位。考虑为利福平所致的色素沉着,将利福平停用,
Patient hospital number 22507, female, 23 years old, admitted to hospital on June 21, 1980 for hematogenous disseminated tuberculosis with tuberculous meningitis. With streptomycin, isoniazid and intravenous infusion of sodium salina, oral prednisone treatment. On July 14 appeared on the sodium salicylate caused fever, drug eruption and other allergic reactions, stop dropping on the sodium salicylate after July 23 and rifampicin 600 mg / day orally (Jinzhou Pharmaceutical Factory in 1980 ), To August 4 and began to heat, feeling double finger numbness, and nausea, vomiting and other symptoms. On August 11, it was found that the palmar and plantar surfaces of both hands were orange-red in color. The local tactile and pain-like sensations seemed to be slightly weakened. The other areas had normal skin color and no yellow stained sclera and normal liver function. The index of jaundice was 5 units. Consider rifampin-induced pigmentation, the use of rifampin disabled,