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目的:探讨胃肠道间质瘤(GIST)的组织形态学特征及对该类肿瘤的诊断及预后问题。方法:对发生于2001年4月至2010年4月间的50例GIST进行临床病理及免疫组化分析。结果:50例GIST免疫组化检查结果,肿瘤均不表达CK而表达为Vime-ntin;CD117阳性表达43例,CD34阳性表达38例;S100均有不同程度表达,SMA阳性表达22例,Desmin阳性表达15例;Ki-67均有表达,其阳性度从+-++不等。结论:本组肿瘤中所有病例均不同程度表达Ki-67和PCNA,高危险性的阳性表达强、低危险性的阳性表达弱,这说明GIST的预后除与肿瘤的大小、组织形态学的改变及肿瘤的发生部位有关外,还与Ki-67和PCNA在肿瘤中的表达程度有关。
Objective: To investigate the histomorphological characteristics of gastrointestinal stromal tumors (GIST) and the diagnosis and prognosis of these tumors. Methods: Fifty cases of GIST that occurred between April 2001 and April 2010 were analyzed by clinicopathological and immunohistochemical methods. Results: The immunohistochemical results of 50 cases of GIST showed no expression of CK and Vime-ntin in all the tumors, 43 cases of CD117 positive and 38 cases of CD34 positive, S100 all expressed in varying degrees, 22 cases positive for SMA, 15 cases were expressed; Ki-67 was expressed, its positive degree ranged from + - ++. Conclusions: Ki-67 and PCNA are all expressed in all cases in this group. The positive expression of high-risk and low-risk is weak, which indicates that the prognosis of GIST is not related to the size of the tumor, the change of histomorphology And the tumor site, but also with the expression of Ki-67 and PCNA in the tumor.