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肿瘤的转移是其致死性的主要原因 ,其过程包括从肿瘤的原发部位脱离 ,进入周围的基质 ,进入循环或淋巴系统 ,粘附在内皮细胞壁并向血管外迁移及在远处侵润 ,血管增生 ,形成新的转移灶。这一过程包含复杂的分子机制 ,计多粘附分子、蛋白溶酶、细胞因子和生长因子参与了这一过程 ,本文将从粘附分子、蛋白溶酶和血管增生三方面将近年来的发展加以综述
Tumor metastasis is the main cause of its death. The process includes detachment from the primary site of the tumor, entering the surrounding matrix, entering the circulation or lymphatic system, adhering to the endothelial cell wall and migrating out of the blood vessel and infiltrating in the distance. Vascular proliferation, the formation of new metastases. This process involves a complex molecular mechanism that involves the involvement of multiple adhesion molecules, plasmin, cytokines, and growth factors. This article will examine recent developments in three aspects: adhesion molecules, plasmin, and vascular proliferation. Review