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线粒体是细胞内能量代谢的重要场所。糖、脂肪及氨基酸最终要在线粒体内氧化。释放的能量储存于三磷酸腺苷的高能磷酸键中。这就是为生命提供主要能源的氧化磷酸化作用。在创伤或失血对细胞损伤的研究中,人们十分重视线粒体结构及氧化磷酸化功能的改变。sayeed等提出线粒体功能的改变与休克死亡休戚相关。因此,研究不同程度的出血性休克对线粒体结构与功能的影响,有助于了解失血性休克造成细胞损伤的机制,进而提出防治休克的合理措施(文献从略)。
Mitochondria are important places for intracellular energy metabolism. Sugar, fat and amino acids eventually oxidize within the mitochondria. The released energy is stored in the high-energy phosphate bond of adenosine triphosphate. This is the main source of oxidative phosphorylation for life. In the study of trauma or blood loss on cell damage, people pay great attention to the changes of mitochondrial structure and oxidative phosphorylation. Sayeed et al proposed changes in mitochondrial function and death related to shock. Therefore, studying the effects of hemorrhagic shock to different degrees on the structure and function of mitochondria will help to understand the mechanism of cell damage caused by hemorrhagic shock, and then put forward reasonable measures to prevent and treat shock (omitted from the literature).