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A series of antitumor compounds with indolecarbazole structure modified by amino acid and piperidine were designed and synthesized. The indolecarbazole parent nucleus was firstly synthesized, condensed with bromine substituted amino acid methyl ester, then hydrolyzed and condensed with piperidine to produce the target compounds. In vitro cytotoxin activity test was performed against 7 target compounds with methylthiazolyldiphenyl-tetrazolium bromide(MTT), and the results showed that compounds CZ-2, CZ-3 and CZ-5 have higher activity against human colon cancers(HT-29) and(HCT-8), hepatocellular carcinoma(Bel-7402), NSCLC(A549) and breast cancer(MCF-7) cells as compared with the positive control JDC-108.
A series of antitumor compounds with indolecarbazole structure modified by amino acid and piperidine were designed and synthesized. The indolecarbazole parent nucleus was previously synthesized, condensed with bromine substituted amino acid methyl ester, then hydrolyzed and condensed with piperidine to produce the target compounds. cytotoxin activity test was performed against 7 target compounds with methylthiazolyldiphenyl-tetrazolium bromide (MTT), and the results showed that compounds CZ-2, CZ-3 and CZ-5 have higher activity against human colon cancers (HT- -8), hepatocellular carcinoma (Bel-7402), NSCLC (A549) and breast cancer (MCF-7) cells as compared with the positive control JDC-108.