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Rifamethoprim胶囊每粒含利福平0.15g和甲氧苄啶0.04g。此药的特点是具有广谱抗菌作用,对葡萄球菌包括耐甲氧西林菌株,链球菌、肠球菌、分枝杆菌属、梭菌属均有强抗菌活性;大多数肠杆菌科、嗜血菌属、假单胞菌50%以上菌种、革兰氏阳性和革兰氏阴性非产芽胞厌氧菌、军团菌和枝原体属也对其敏感。Rifamethoprim中的两种抗菌药物具有不同的抗菌机理:利福平抑制依赖DNA的RNA聚合酶的合成,而甲氧苄啶则对二氢叶酸还原酶具有抑制作用;因而两药伍用具有协同作用。在复合制剂中,
Rifamethoprim capsules each contain rizafin 0.15g and trimethoprim 0.04g. The drug is characterized by broad-spectrum antibacterial effect against Staphylococcus aureus, including methicillin-resistant strains, Streptococcus, Enterococcus, Mycobacterium, Clostridium have strong antibacterial activity; most Enterobacteriaceae, Haemophilus More than 50% of the genus Pseudomonas species, Gram-positive and Gram-negative non-spore-forming anaerobes, Legionella and Mycoplasma are also sensitive. The two antibacterials in Rifamethoprim have different antimicrobial mechanisms: rifampicin inhibits DNA-dependent RNA polymerase synthesis, whereas trimethoprim has an inhibitory effect on dihydrofolate reductase; thus, two drugs have a synergistic effect . In the complex preparation,