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用放免法测定76例自身免疫性甲状腺疾病及正常对照组的血、尿β_2-微球蛋白水平。结果:Graves病未缓解组、桥本氏病组血、尿β_2-微球蛋白较对照组明显升高(P<0.001),Graves病缓解组、特发性甲减组与对照组差异无显著性(P>0.05)。Graves病缓解组较Graves病未缓解组明显降低(P<0.01)。提示β_2-微球蛋白水平测定可做为自身免疫性甲状腺疾病诊断、疗效观察及了解其免疫状态的一项指标。
76 cases of autoimmune thyroid disease and normal control group blood and urine β_2-microglobulin levels by radioimmunoassay. Results: Serum and urinary β_2-microglobulin levels in Hashimoto’s disease group were significantly higher than those in control group (P <0.001), but there was no significant difference between Graves disease eradication group, idiopathic hypothyroidism group and control group (P> 0.05). Graves disease remission group than Graves disease remission group was significantly lower (P <0.01). Tip β_2 microglobulin levels can be used as a diagnosis of autoimmune thyroid disease, the efficacy of observation and understanding of the immune status of an indicator.