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肌卫星细胞及其子代成肌前体细胞在骨骼肌再生中起关键作用。衰老引起肌卫星细胞数量减少,骨骼肌的再生修复能力受损,肌细胞凋亡速度加快,最终导致肌肉萎缩、肌肉力量下降。SIRT1是一种NAD+依赖的组蛋白去乙酰化酶,介导能量代谢调节、细胞增殖分化、氧自由基代谢、基因表达等多种生理过程。SIRT1可通过调节肌卫星细胞的活化、增殖、分化,对骨骼肌的再生能力产生影响。运动训练上调SIRT1的活性和表达水平,促进SC的活化增殖,改善骨骼肌再生。
Muscle satellite cells and their progenitor myoblasts play a key role in skeletal muscle regeneration. Aging causes decreased numbers of muscle satellite cells, impaired regenerative repair of skeletal muscle, accelerated myocyte apoptosis, and eventually muscle atrophy and decreased muscle strength. SIRT1 is an NAD + -dependent histone deacetylase that mediates various physiological processes such as energy metabolism regulation, cell proliferation and differentiation, oxygen free radical metabolism and gene expression. SIRT1 can affect the regeneration of skeletal muscle by regulating the activation, proliferation and differentiation of muscle satellite cells. Exercise training upregulates the activity and expression of SIRT1, promotes the activation and proliferation of SC, and improves the regeneration of skeletal muscle.