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应用放射免疫测定法测定18例正常人（A组）、16例肺心病急性期（B组）、12例肺性脑病（C组）及14例肺心病伴心力衰竭（D组）患者治疗前后血浆强啡肽A（1～13）（DynA（1～13））及血流动力学参数，观察其动态变化及其相关性。结果显示：B、C、D三组血流动力学参数与A组差异显著（P＜0．01），三组患者治疗前后血浆DynA（1～13）含量与多项血流动力学参数存在显著相关性。DynA（1～13）与血流动力学参数的逐步回归分析，显示其间存在着密切的正相关关系（P＜0．01）。表明肺动脉高压、缺氧和高碳酸血症是密切相关的原因。
The radioimmunoassay was used to determine the plasma levels of 18 normal individuals (group A), 16 patients with acute cor pulmonale (group B), 12 patients with pulmonary encephalopathy (group C) and 14 patients with pulmonary heart disease with heart failure (group D) Plasma Dynorphin A (1 ~ 13) (DynA (1 ~ 13)) and hemodynamic parameters were observed and their dynamic changes and their correlation were observed. The results showed that the hemodynamic parameters in group B, C and D were significantly different from those in group A (P <0.01). Before and after treatment, the levels of plasma DynA (1 ~ 13) and the number of hemodynamic parameters Significant correlation. Stepwise regression analysis of DynA (1 ~ 13) and hemodynamic parameters showed that there was a close positive correlation (P <0.01). That pulmonary hypertension, hypoxia and hypercapnia are closely related reasons.