Streptozotocin-induced expression of Ngn3 and Pax4 in neonatal rat pancreatic α-cells

• 作 者: Xiao-Di Liang Yuan-Yuan Guo Mi
• 机 构: Department＆BiochemistryandMo-lecularBiology
• 出 处: 世界胃肠病学杂志：英文版
• 发表日期: 2011年23期
• 关键词: 新生大鼠 胰腺 诱导表达 细胞治疗 细胞再生 转录因子 免疫荧光染色 前体细胞 Pancreatic remodeling DedifferentiationE
• 基金项目: Supported by The National Natural Science Foundation of China,No. 81070620

AIM:To investigate the mechanism behind β-cell regeneration in neonatal rat pancreas treated with streptozotocin (STZ).METHODS:Neonatal Sprague Dawley rats were intraperitoneally injected with 70mg/kg STZ.Body weight,pancreas weight and blood glucose were