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T淋巴细胞在胸腺这一独特微环境中发育分化成幼稚CD4T淋巴细胞、幼稚CD8T淋巴细胞、调节性T淋巴细胞等不同细胞亚群,然后在一定条件下离开胸腺到外周淋巴组织器官,接触抗原后在不同的细胞因子作用下进一步成熟分化为不同的功能性亚群。CD4T淋巴细胞分化为Th1、Th2、Th17;调节性T淋巴细胞分为天然型和诱导型;CD8T淋巴细胞分化为记忆、效应以及调节/抑制性CD8T淋巴细胞。功能不同的T淋巴细胞亚群主导着不同的自身免疫性疾病。
T lymphocytes differentiate into naive CD4 T lymphocytes, naive CD8 T lymphocytes, regulatory T lymphocytes and other different cell subpopulations in this unique microenvironment of the thymus, and then leave the thymus to peripheral lymphoid tissues and organs under certain conditions and contact antigen After different cytokines further mature differentiated into different functional subgroups. CD4T lymphocytes differentiate into Th1, Th2, Th17; regulatory T lymphocytes are divided into natural and inducible; CD8T lymphocytes differentiate into memory, effector and regulatory / inhibitory CD8 T lymphocytes. Different T-lymphocyte subsets dominate different autoimmune diseases.