【摘 要】
：
目的 探讨阿托伐他汀和氯吡格雷对急性冠状动脉综合征(ACS)患者血小板聚集率的影响.方法 选择66例ACS患者作为ACS组,25例健康志愿者作为对照组.ACS组患者在常规药物治疗基础
【机 构】
：
甘肃省第二人民医院重症医学科,甘肃省第二人民医院心内科,甘肃省第二人民医院急诊科
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目的 探讨阿托伐他汀和氯吡格雷对急性冠状动脉综合征(ACS)患者血小板聚集率的影响.方法 选择66例ACS患者作为ACS组,25例健康志愿者作为对照组.ACS组患者在常规药物治疗基础上均予阿司匹林(100 mg/d)、氯吡格雷(75 mg/d)和阿托伐他汀(20 mg/d)治疗.对照组志愿者均予阿司匹林肠溶片、氯吡格雷和阿托伐他汀口服,药品来源、剂量与ACS组相同.采用流式细胞仪测定上述受试者的血小板聚集率.结果 对照组志愿者分别采用双联抗血小板联合阿托伐他汀治疗以及双联抗血小板治疗,血小板聚集率分别为(44.27±16.37)%、(47.61±16.67)%,二者差异无统计学意义(P>0.05).ACS组患者采用上述2种方法治疗,血小板聚集率分别为(47.70±15.07)%、(47.03±15.45)%,二者差异无统计学意义(P>0.05).结论 氯吡格雷与阿托伐他汀联合治疗不影响氯吡格雷的抗血小板作用,二者无相互作用.
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