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应用彩色多普勒血流显像技术监测了３１例妊娠高血压综合征（以下简称妊高征）及７４例正常孕妇子宫胎盘血液循环变化，同时测定了血中雌三醇（Ｅ_３）、胎盘生乳素（ＨＰＬ）、血栓素Ｂ_２（ＴＸＢ_２）、６－酮－前列环素（６－ｋｅｔｏ－ＰＧＦ_（１α））及ＴＸＢ_２／６－ｋｅｔｏ－ＰＧＦ_（１α）比值．结果：妊高征孕妇子宫动脉及胎儿脐动脉的时间平均血流速度（ＴＡＶ）、血流量（Ｑ）明显低于正常孕妇（Ｐ＜０．０５），尤以重度妊高征明显．妊高征病例经用硫酸镁及青心酮治疗后，子宫胎盘血液循环明显改善，子宫动脉及脐动脉的ＴＡＶ、Ｑ均增加（Ｐ＜０．０５）；其血中Ｅ_３及ＨＰＬ浓度明显低于正常孕妇，ＴＸＢ_２／６－ｋｅｔｏ－ＰＧＦ_（１α）比值明显高于正常孕妇．结果显示，用彩色多普勒观察妊高征患者的子宫动脉及脐动脉ＴＡＶ、Ｑ，可以直接反映子宫胎盘血供情况，为了解胎盘功能及宫内胎儿安危状况提供了一条有价值的参数．
The changes of blood circulation in 31 cases of pregnancy induced hypertension (PIH) and 74 cases of normal pregnant women were monitored by color Doppler flow imaging. Serum levels of estriol (E_3), placenta HPL, TXB_2, 6-keto-PGF_ (1α) and TXB_2 / 6-keto-PGF_ (1α) ratio were measured. Results: The mean blood flow velocity (TAV) and blood flow (Q) of uterine artery and fetal umbilical artery in PIH were significantly lower than those in normal pregnant women (P <0.05), especially severe PIH. The cases of PIH were treated with magnesium sulfate and chingxin ketone, the blood circulation of uterine placenta was significantly improved, and the TAV and Q of uterine artery and umbilical artery were increased (P <0.05). The concentrations of E_3 and HPL in blood were significantly lower In normal pregnant women, the ratio of TXB_2 / 6-keto-PGF_ (1α) was significantly higher than that of normal pregnant women. The results showed that the observation of color Doppler in uterine artery and umbilical artery TAV, Q, can directly reflect the uterine placental blood supply, in order to understand the placental function and intrauterine fetal safety status provides a valuable parameter.