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细胞免疫在肿瘤、病毒感染、自身免疫病中的重要作用久已被关注。早在七十年代,人们试图用细胞免疫产物-TF来防治肿瘤、病毒感染;干扰素也是众所周知的细胞免疫产物,它已从抗病毒发展到抗肿瘤及免疫调节等;最近,Rosenberg等创建用淋巴因子之一的IL-2活化杀伤细胞(LAK)治疗肿瘤后又将细胞免疫推向更高阶段。然而,发挥细胞免疫的T细胞活化机理所知不多,尤其
The important role of cellular immunity in tumors, viral infections and autoimmune diseases has long been a concern. As early as the seventies, people tried to use the cellular immune product -TF to prevent tumor and virus infection. Interferon is also a well-known cellular immune product that has developed from antiviral to anti-tumor and immune regulation. Recently, Rosenberg et al. IL-2-activated killer cells (LAKs), one of the lymphokines, treat the tumor and then push cellular immunity to a higher stage. However, little is known about the mechanism of T cell activation that exerts cellular immunity, in particular