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ｂｃｌ 2及其同源类似物是凋亡调节因子中最重要的家族之一。ｂｃｌ 2家族蛋白能通过多种方式调节细胞死亡途径 :(1)与其他ｂｃｌ 2家族成员二聚化形成同源或异源二聚体 ,且可能通过相互作用改变细胞生与死平衡 ;(2 )与非同源性蛋白结合 ;(3)形成离子通道或孔洞[1] 。Ｂａｘ基
Bcl 2 and its homologues are among the most important families of apoptosis regulators. Bcl 2 family proteins can regulate cell death pathways in many ways: (1) dimerize with other bcl 2 family members to form homo- or hetero-dimers, and may alter the balance of cell life and death through interaction; (2 ) binding to non-homologous proteins; (3) formation of ion channels or pores [1]. Bax-based