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目的观察2种浓度去甲肾上腺素洗胃液在有机磷农药中毒急救中的临床疗效。方法选取医院收治的有机磷农药中毒患者48例,依据药物浓度不同分为对照组和观察组,每组24例。对照组采用0.001%去甲肾上腺素洗胃液治疗,观察组采用0.008%去甲肾上腺素洗胃液治疗。观察比较2组患者阿托品用药总量、出现阿托品化时间、胆碱酯酶恢复时间、住院时间、收缩压及低钠血症、消化道黏膜出血发生情况。结果 2组患者收缩压比较,差异无统计学意义(P>0.05);与对照组比较,观察组阿托品用药总量少,胆碱酯酶恢复、出现阿托品化及住院时间短,差异显著均有统计学意义(P<0.01);观察组低钠血症及消化道黏膜出血发生率均低于对照组(P<0.05)。结论0.008%去甲肾上腺素洗胃液应用于有机磷农药中毒治疗中,可迅速阿托品化,促进胆碱酯酶恢复,减少阿托品用量,缩短住院时间,降低低钠血症、消化道黏膜出血发生率,在临床治疗中具有重要意义。
Objective To observe the clinical efficacy of two concentrations of norepinephrine gastric lavage fluid in emergency treatment of organophosphorus pesticide poisoning. Methods Forty-eight patients with organophosphorus pesticide poisoning admitted to hospital were divided into control group and observation group according to different drug concentrations, with 24 cases in each group. The control group was treated with 0.001% norepinephrine gastric lavage fluid, while the observation group was treated with 0.008% norepinephrine gastric lavage fluid. Observed and compared the total amount of atropine medication in two groups of patients with atropisol time, cholinesterase recovery time, hospital stay, systolic blood pressure and hyponatremia, gastrointestinal mucosal bleeding. Results There was no significant difference in systolic blood pressure between the two groups (P> 0.05). Compared with the control group, the total amount of atropine used in the observation group was less, the recovery of cholinesterase, the occurrence of atropine and shorter hospital stay were significant (P <0.01). The incidences of hyponatremia and gastrointestinal mucosal hemorrhage in the observation group were lower than those in the control group (P <0.05). Conclusion 0.008% norepinephrine gastric juice was used in the treatment of organophosphorus pesticide poisoning, which could rapidly atropine, promote the recovery of cholinesterase, reduce the amount of atropine, shorten the hospital stay, reduce the incidence of hyponatremia, gastrointestinal mucosal hemorrhage , In clinical treatment is of great significance.