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恶性疟原虫对氯喹的抗性,是恶性疟疾流行区防治工作急需弄清和解决的主要问题。1973年,国内首次报告云南省孟定地区存在抗氯喹株恶性疟原虫,引起了我们对抗氯喹疟疾的警惕和重视。1974年,我们按照世界卫生组织介绍的恶性疟原虫对氯喹敏感性测定方法,在崖县南滨和乐东县志仲两地,对67例现症病人进行调查,结果在崖县发现1例二级抗性病例。1975年进一步调查证实,乐东县中部存在一个抗性流行区。1976年,结合我区的实际情况,简化调查方法,组织基层力量,扩大调查面,初步查清乐东及其
The resistance of Plasmodium falciparum to chloroquine is the major problem urgently needed to be clarified and resolved in the prevention and control of the endemic area of malaria. In 1973, the first report of the existence of anti-chloroquine-resistant Plasmodium falciparum in Mengding, Yunnan Province caused our vigilance and resistance against chloroquine malaria. In 1974, according to the WHO method for the determination of chloroquine susceptibility of Plasmodium falciparum, we conducted a survey of 67 cases of endemic diseases in Nanbin, Laxian County and Zhizhong County, Ledong County. As a result, one case of II Grade resistant cases. Further investigation in 1975 confirmed that there was a resistance epidemic area in central Ledong County. In 1976, according to the actual situation in our district, simplifying the methods of investigation, organizing the grassroots forces, expanding the survey area and initially identifying Ledong and its