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[目的]探究右美托咪定联合舒适性疏导对小儿全麻苏醒期躁动的影响.[方法]前瞻性选择2016年3月至2018年6月本院收治的拟行全麻下腺样体扁桃体切除术的153例患儿纳入本研究.根据随机数表法将其分为右美托咪定组、联合组、对照组,每组各51例.右美托咪定组、联合组均于气管插管后给予右美托咪定泵注(对照组泵注等量生理盐水),联合组于术前加用舒适性疏导.比较三组患儿生理状态变化、拔管后1~4hRam-say镇静评分变化以及苏醒时间、躁动评分、躁动发生率.[结果]三组患儿苏醒后10~60 min时心率(HR)均较苏醒时下降,右美托咪定组苏醒时HR低于对照组,联合组苏醒时HR低于右美托咪定组,差异有统计学意义(P<0.05).三组患儿拔管后2~4h时Ramsay评分均较拔管后1h升高,右美托咪定组拔管后1h、2h、4hRam-say评分均高于对照组,联合组拔管后1h、2h、3h、4hRamsay评分高于右美托咪定组,差异均有统计学意义(P<0.05).对照组苏醒时躁动评分低于右美托咪定组,右美托咪定组苏醒时躁动评分低于联合组,差异有统计学意义(F=5.879,P=0.000).对照组躁动发生率为29.41%(15／51)高于右美托咪定组的15.69%(8／51),右美托咪定组躁动发生率亦高于联合组的3.92%(2／51),差异有统计学意义(χ2=3.015,P=0.013).[结论]右美托咪定能够在不影响麻醉安全性的前提下,有效预防小儿全麻苏醒期躁动,在此基础上,联合舒适性疏导能够进一步提高躁动的预防效果.“,”[Objective]ToexpLoretheeffectofdexmedetomidinecombinedwithcomfortcounseLingonrest-LessnessduringrecoveryperiodofgeneraLanesthesiainchiLdren,andtoanaLyzeitscLinicaLappLicationvaLue.[Methods]Onehundredandfifty-fourcasesofadenoidectomyundergeneraLanesthesiainourhospitaLfrom March 2016toJune2018 wereseLectedforprospectivecontroLstudy.ThechiLdren weredividedintodexmedetomidine group,combinationgroupandcontroLgroupbyrandomnumbertabLemethod,51casesineachgroup.Aftertra-cheaLintubation,dexmedetomidinegroupandcombinationgroupweregivendexmedetomidinepumpinjection(the controLgroupwaspumpedwiththesameamountofsaLine).ThecombinationgroupwasgivencomfortabLecounse-Lingbeforeoperation.ThechangesofphysioLogicaLstate,Ramsaysedationscore1-4hoursafterextubation,recov-erytime,restLessnessscoreandnumberofrestLessnesscaseswerecomparedamongthethreegroups.Theanes-theticeffectandsafetyofdifferentschemesandtheireffectsonrestLessnessduringtherecoveryperiodofgeneraL anesthesiawereanaLyzed.[ResuLts]Heartrate (HR)decreased10to60 minutesafterawakeninginaLLthree groups.HRinthedexmedetomidinegroupwasLowerthanthatinthecontroLgroup,and HRinthecombination groupwasLowerthanthatinthedexmedetomidinegroup(P<0.05).Ramsayscoresofthethreegroupsat2~4 hoursafterextubationwerehigherthanthoseat1hourafterextubation.Ramsayscoresofthedexmedetomidine groupat1h,2hand4hafterextubationwerehigherthanthoseofthecontroLgroup.Ramsayscoresofthecom-binedgroupat1h,2h,3hand4hafterextubationwerehigherthanthoseofthedexmedetomidinegroup,with statisticaLsignificance(P<0.05).TherestLessnessscoreofthecontroLgroupwasLowerthanthatofthedexme-detomidinegroup,andtherestLessnessscoreofthedexmedetomidinegroupwasLowerthanthatofthecombination group (F=5.879,P=0.000).TheincidenceofrestLessnessinthecontroLgroupwas29.41% (15／51)higherthan thatinthedexmedetomidinegroup15.69% (8／51),andthatinthedexmedetomidinegroupwas3.92% (2／51) higherthanthatinthecombinationgroup (χ2=3.015,P=0.013).[ConcLusion]DexmedetomidinecaneffectiveLy preventrestLessnessduringtherecoveryperiodofgeneraLanesthesiainchiLdrenwithoutaffectingthesafetyofan-esthesia.Onthisbasis,combinedcomfortcounseLingcanfurtherimprovethepreventiveeffectofrestLessness.