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目的观察槐定碱(SR)对麻醉大鼠杏仁核脑区生物电信号(EEG)变化的影响。方法利用脑立体定位技术,将电极置入大鼠杏仁核,采用单极引导法及计算机辅助傅里叶变换技术(FFT)记录并分析槐定碱对大鼠杏仁核脑区生物电变化的影响。结果与对照组比较,每只大鼠侧脑室注射0.1、0.2、0.4mgSR后,大鼠出现明显的躁动、杏仁核区脑电出现异常去同步化,痫样放电持续时间和频率均表现出明显差异性(P<0.05、P<0.01),并呈剂量依赖关系。结论 SR具有明显的中枢兴奋作用,其作用与增强杏仁核脑区的电活动有关;杏仁核可能是槐定碱中枢兴奋作用传导通路上的重要结构之一。
Objective To observe the effects of sophoridine (SR) on changes of bioelectrical signal (EEG) in the amygdala of anesthetized rats. Methods Electrodes were implanted into the amygdala of rats using stereotactic technique. The monopolar guidance method and computer-aided Fourier Transform (FFT) technique were used to record and analyze the effects of sophoridine on the bioelectrical changes in the rat amygdala. . Results Compared with the control group, each rat injected 0.1, 0.2 and 0.4 mg of SR into the lateral ventricle, the rats showed obvious agitation. The anamorphic amygdala showed abnormal desynchronization, and the duration and frequency of epileptiform discharge showed obvious (P <0.05, P <0.01), and in a dose-dependent manner. Conclusion SR has obvious central excitatory effect, and its role is related to the enhancement of electrical activity in the amygdala. Brain amygdala may be one of the important structures of the spermine base conduction pathway.