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目的探讨重症肺炎患儿氨基末端脑钠肽前体(NT-proBNP)和降钙素原(PCT)的变化。方法选取重症肺炎患儿96例,根据PCT升高的程度分为2组,PCT<2.00 ng/ml组和PCT≥2.00 ng/ml组;另选取89例因非感染性疾病入院且住院期间未发生感染者作为对照组。检测并采用秩和检验方法分析比较各组的PCT和NT-proBNP水平,采用卡方检验方法分析比较不同PCT水平的重症肺炎患儿心力衰竭发生率。结果与对照组比较,重症肺炎组PCT、NTproBNP水平明显升高,差异均有统计学意义(P<0.05);PCT≥2.00 ng/ml组的NT-proBNP水平相比PCT<2.00 ng/ml组较高,差异有统计学意义(P<0.05);PCT≥2.00 ng/ml组的患儿心力衰竭发生率(56.52%)高于PCT<2.00 ng/ml组(32.88%),差异有统计学意义(χ~2=4.128,P=0.042)。结论重症肺炎患儿易发生心力衰竭,PCT水平越高,越容易并发心力衰竭。
Objective To investigate the changes of amino-terminal pro-brain natriuretic peptide (NT-proBNP) and procalcitonin (PCT) in children with severe pneumonia. Methods Ninety-six children with severe pneumonia were selected and divided into 2 groups according to the degree of PCT increase: PCT <2.00 ng / ml group and PCT≥2.00 ng / ml group. Another 89 patients were admitted to hospital due to noninfectious disease and were not hospitalized Infection occurred as a control group. The levels of PCT and NT-proBNP in each group were analyzed by rank sum test. The chi-square test was used to analyze the incidence of heart failure in children with severe pneumonia at different PCT levels. Results Compared with the control group, the levels of PCT and NTproBNP in severe pneumonia group were significantly higher than those in control group (P <0.05); NT-proBNP level in PCT≥2.00 ng / ml group was significantly lower than that in PCT group <2.00 ng / ml (P <0.05). The incidence of heart failure in children with PCT≥2.00 ng / ml (56.52%) was higher than that in PCT <2.00 ng / ml (32.88%), the difference was statistically significant Significance (χ ~ 2 = 4.128, P = 0.042). Conclusion Children with severe pneumonia are prone to heart failure. The higher the PCT level, the more likely it is to develop heart failure.