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目的：比较大鼠精神性（ 束缚） 和生物性（ 脓毒败血症） 应激时不同组织中降钙素基因相关肽（ｃａｌｃｉｔｏｎｉｎｇｅｎｅｒｅｌａｔｅｄ ｐｅｐｔｉｄｅ，ＣＧＲＰ）含量的变化。方法：盲肠结扎并以１８ 号针穿刺，制备１０ ｈ 和２０ ｈ 大鼠腹膜炎脓毒血症模型。将大鼠固定２０ ｈ 制备束缚应激模型，以放免法测定６ 种组织（ 细胞） 中ＣＧＲＰ 的含量。结果：腹膜炎脓毒血症早期时，脊髓背根神经节、肠系膜上动脉和十二指肠中ＣＧＲＰ明显升高，晚期时胸腺细胞中ＣＧＲＰ明显升高，气管中ＣＧＲＰ持续升高，心房中ＣＧＲＰ含量呈增高趋势。而束缚应激时仅胃肠道和肠系膜上动脉ＣＧＲＰ含量有明显改变。结论：在不同应激刺激下，神经源和免疫源ＣＧＲＰ 的合成和释放的特点不同。精神应激可能不直接刺激ＣＧＲＰ释放，后者对感染、失血和创伤等刺激更为敏感。
OBJECTIVE: To compare the changes of calcitonin gene related peptide (CGRP) in different tissues of rats in psychic (restraint) and biological (septic sepsis) stress. Methods: The caecum was ligated and punctured with needle 18 to prepare the model of peritonitis sepsis for 10 h and 20 h. The rats were fixed for 20 h to prepare restraint stress model, and the content of CGRP in 6 tissues (cells) was determined by radioimmunoassay. Results: CGRP in dorsal root ganglia, superior mesenteric artery and duodenum was significantly increased in early stage of peritonitis sepsis. CGRP in thymocytes was significantly increased in late stage, and CGRP in trachea continued to increase. CGRP in atrium The content showed an increasing trend. However, only the CGRP content in the gastrointestinal tract and superior mesenteric artery was significantly changed when restraint stress was applied. CONCLUSIONS: The neuronal and immunogenic CGRP have different characteristics of synthesis and release under different stress stimuli. Mental stress may not directly stimulate the release of CGRP, the latter is more sensitive to infection, blood loss and trauma and other stimuli.