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曾有报道,当地高辛与白陶土果胶混悬液同服时,地高辛的生物利用度明显降低。然而,这些观察只是来自地高辛单剂量的研究,而并非对临床密切相关的长期地高辛疗法的研究。当投予长时期的地高辛后再加服白陶土果胶止泻合剂,对口服地高辛的稳态血药浓度的影响作了研究。采用两种实验操作是——一是将地高辛与白陶土果胶混悬液同时服用;二是在服用地高辛2小时前和2小时后分别服用白陶土果胶混悬液。
It has been reported that the bioavailability of digoxin is obviously reduced when the local digoxin and kaolin suspension are used in the same dosage. However, these observations are from a single dose of digoxin study, not a study of long-term digoxin therapy that is clinically relevant. The effects of orally administered digoxin on steady-state plasma concentrations were investigated when long-term digoxin was added followed by cedilamine-pectin anti-diarrhea mixture. Two experimental procedures were used - one was to take digoxin and the kaolin suspension simultaneously; the other was to take the kaolin suspension two and two hours before taking digoxin.