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目的探讨对比同一药物采用静脉全身化疗与经动脉灌注局部化疗治疗肺癌的效果。方法 160例肺癌患者根据入院顺序分为治疗组与对照组各80例,两组均选择顺铂化疗,对照组采用传统静脉全身用药,治疗组采用经动脉灌注局部化疗。结果治疗组有效率为80.0%,对照组为55.0%,两组患者有效率差异有统计学意义(P<0.05)。两组患者化疗前功能状态(KPS)评分对比无明显差异,化疗组间与组内比较差异有统计学意义(P<0.05)。随访6个月,治疗组恶心、呕吐、食欲减退等总体并发症发生率明显低于对照组(P<0.05)。随访2年,治疗组的平均生存期、1年生存率和2年生存率都明显高于对照组(P<0.05)。结论经动脉灌注局部顺铂化疗相较于静脉全身化疗,可提高肺癌的治疗效果,减轻症状,降低不良反应,提高远期生存率,有很好的临床应用价值。
Objective To compare the effects of intravenous systemic chemotherapy and arterial infusion of local chemotherapy on the same drug in the treatment of lung cancer. Methods One hundred and sixty patients with lung cancer were divided into treatment group and control group according to the sequence of hospitalization, 80 patients in each group were treated with cisplatin and the control group was treated with traditional intravenous systemic administration. The patients in the treatment group were given local chemotherapy via arterial infusion. Results The effective rate was 80.0% in the treatment group and 55.0% in the control group, with significant difference between the two groups (P <0.05). There was no significant difference in KPS score between the two groups before chemotherapy, and there was significant difference between chemotherapy group and control group (P <0.05). The follow-up 6 months, the treatment group nausea, vomiting, loss of appetite and other overall complication rate was significantly lower than the control group (P <0.05). After 2 years of follow-up, the mean survival time, 1-year survival rate and 2-year survival rate of the treatment group were significantly higher than those of the control group (P <0.05). Conclusion Intra-arterial infusion of cisplatin compared with intravenous systemic chemotherapy, can improve the treatment of lung cancer, reduce symptoms, reduce adverse reactions and improve long-term survival rate, has a good clinical value.