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慢性乙型肝炎不仅与乙型肝炎病毒(HBV)的活跃复制有关,还与HBeAg阳性期疾病的快速发展有关。有人报道由于HBV前C区突变导致肝细胞不能分泌HBeAg,抗-HBe阳性患者的HBV复制活性很高,疾病发展仍然很快。但由于前C区的功能仅是从肝细胞中产生和分泌HBeAg,而与病毒复制无关,则必然有其他因素影响HBV的复制。在HBV基因组编码区,X区是复制所必需的。它不仅含有核心启动子、核心上游调控序列及一个反式调节因子,而且X蛋白本身就是增强子Ⅱ和核心启动子的反式激活
Chronic hepatitis B is not only associated with the active replication of hepatitis B virus (HBV), but also with the rapid development of HBeAg-positive disease. It has been reported that HBV can not secrete HBeAg due to mutations in the pre-HBV C region, HBV replication activity in anti-HBe positive patients is very high, and the disease is still developing rapidly. However, since the pre-C region functions only to produce and secrete HBeAg from hepatocytes and has nothing to do with virus replication, there are bound to be other factors that affect HBV replication. In the HBV genome coding region, region X is necessary for replication. It contains not only the core promoter, the core upstream regulatory sequence and a trans regulatory factor, but also the X protein itself is the transactivator of enhancer II and core promoter